Dr. Binitha R. N has completed her Bachelor’s, Master’s M.Phil and Ph.D Degrees from Kerala University, showcasing her commitment to education and Research. She was University Rank holder (MSc) and a winner of Young Scientist award. She is recognized as research guide by Mahathma Gandhi university from 2018 onwards. Five research scholars are Pursuing their Ph.D under her guidance and supervision. She was the Principal Investigator of a DST SERB major project “Potential health concern and endocrine disrupting properties of a commonly used anti-oxidant and food preservative BHA” (Completed) and has Completed two minor projects from UGC and RUSA. She has published more than ten Research articles in SCI indexed and UGC care listed journals. And Presented research papers in more than 20 International and National conferences. Her research area zeros- in on a question-oriented approach addressing a range of issues related to endocrine disruption and reproductive endocrinology. Her current research focus on the possible Prostrate and Breast cancer protective role of Phytoestrogens using an integrated -In silico, In vitro and in vivo approaches. Her Research contributions include analysis of every spike (S) protein mutations in all the reported whole-genome sequences of SARS-CoV-2 circulating in India. Study on the use of Phytoestrogens and endocrine disruptors in hormone replacement therapy in the treatment of prostrate and breast cancer, various screening assays for studying the endocrine disrupting properties of food preservatives and anti oxidants like BHA and BHT etc.
She is serving as a nominee of CPCSEA (Ministry of Environment, Forest & Climatic Change, Govt of India). She was a member of PG board of Studies Mahathma Gandhi University, WWS Co-ordinator ( Department of Higher education New initiatives, Govt of Kerala) and IQAC and NIRF Core committee member of the college.
Dr. Binitha. R. N was awarded PhD degree from Kerala University , Research topic was Endocrine Disruptors in sewage effluents and their Physiological effects. She is recognised as a PhD guide in the faculty of Science, M.G university, Kerala. Currently Five Research scholars are pursuing their PhD degree under her guidance and Supervision. Her Core Research area is Effect of various Androgen and estrogenic agonists and antagonists, phytoestrogens, in the normal reproductive physiology of humans and animals. Studies were conducted using various tier screening assays to identify the endocrine disrupting properties of food preservatives and anti oxidants. Now the research team is working on the possible prostrate and Breast cancer protective role of various phytoestrogens.
Research follows an integrated approach – that include computational biology ( molecular docking studies, Studies in various cell lines (in vitro assays) and In vivo assays using experimental Rat and mice as models, make use of Histopathological techniques, techniques in molecular biology and Genomic assays- RT PCR and Blotting techniques, studying the expression of marker genes, Biochemical assays of marker enzymes, and hormonal profiling using ELISA and RIA. In the last five years the research team has contributed many good impact factor publications in SCI indexed journals like Elsevier, Springer and Wiley Online etc.
2023
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Francis, D., Binitha, R.N. and Nissar, R., 2023. Unveiling phytoestrogenic potential of Neolamarkia kadamba: A comprehensive insilico study. Materials Today: Proceedings.
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Nissar, R., Binitha, R.N. and Francis, D., 2023. An insilico approach to investigate the possible prostate cancer protective role of peoniflorin. Materials Today: Proceedings.
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Francis, D., Binitha, R.N. and Nissar, R., 2023. Unveiling phytoestrogenic potential of Neolamarkia kadamba: A comprehensive insilico study. Materials Today: Proceedings.
2022
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Muttineni, R., RN, B., Putty, K., Marapakala, K., KP, S., Panyam, J., ... & Kondapi, A. K. (2022). SARS-CoV-2 variants and spike mutations involved in second wave of COVID-19 pandemic in India. Transboundary and Emerging Diseases, 69(5), e1721-e1733.
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Balachandran, S., Binitha, R. N., & Sunny, F. (2022). Homology in the Binding Patterns of Human and Rat Androgen Receptors with various Ligands. Journal of Endocrinology and Reproduction, 26(1), 35-44.
2021
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Balachandran, S., & Binitha, R. N. (2021). An in silico approach to study the interaction of BHA with selected steroid hormone receptors and investigating it’s agonistic and antagonistic properties. In Silico Pharmacology, 9, 1-12.
2020
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Joseph, R., & Binitha, R. N. (2020). Screening of potential antiandrogenic phytoconstituents and secondary metabolites of Terminalia chebula by docking studies. Materials Today: Proceedings, 25, 316-320.
2018
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Paul, G., Binitha, R. N., & Sunny, F. (2018). Fish short-term reproductive assay for evaluating the estrogenic property of a commonly used antioxidant, butylated hydroxyanisole. Current Science, 115(8), 1584-1587.
2015
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Devi, C.A., Binitha, R.N., Soorya, S.R., Amrutha, B.V. and Sunny, F., 2015. Oxidative stress responses of a freshwater teleost, Anabas testudineus, to an endocrine disruptor, Bisphenol
2013
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Soorya, S.R., Aruna, C.D., Binitha, R.N., Amrutha, B.V., Jayalekshmi, G. and Sunny, F., 2013. Quantitative changes in antioxidant enzyme activities, glutathione content and malondialdehyde in a freshwater fish, Anabas testudineus (Bloch), exposed to sewage. J. Aquat. Biol. Fish, 1, pp.68-76.
2011
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Binitha RN, Soorya SR, Devi CA, Sunny F. Impact of Sewage Effluents on Osmoregulation in a Freshwater Teleost, Anabas testudineus. Journal of Endocrinology and Reproduction. 2011 Jun 1:27-36.
Presentation: International
- Binitha,R.N., Paul George., Francis sunny (2014). Butylated Hydroxy Anisole shows potential endocrine disruption and reproductive impairments in the fresh water teleost, Anabas testudineus. Presented paper in ICPM International Conference on physiology and medicine at Periyar University, Salem Op-85:114.
- R.N.,Binitha., Paul George., Francis Sunny (2015). Anti oxidant and food preservative, Butylated hydroxy Anisole (BHA) as an endocrine disruptor affects male gonad development and reproduction in Anabas testudineus. International symposeum on Comparative Endocrinology and Integrative physiology Op 38 : 75
- Attend International Workshop on Comprehensive Toxicology by association of Toxicology (27 to 31 st July 2015) at Bangalore.
- Binitha.R.N and Paul George (2016) Potential Health Concern and Endocrine disrupting properties of the commonly used anti oxidant butylated hydroxy anisole ( BHA) . Lasacon International conference on Advances in Laboratory
- Animal science for modelling Human Diseases.
- Hands on Workshop for handling and care of laboratory animals organised by CPCSEA at School of Life sciences JNU( 14-16 February 2016)
- Biny,N.B and Binitha.R.N (2021) Histopathology as a tool for studying the reproductive effects of Butylated Hydroxy toluine in a fresh water teleost, Anabas testudineus.4th interdisciplinary International Conference on Green development in tropical region. University of Andalas.Indonesia.( 7-8 July). (Won best presenter award)
Presentation: National
- Binitha, R.N., Francis Sunny., Oommen, O.V., 2006; Altered Testes and occurrence of Ovotestis in a fresh water fish Anabas testudineus, Evidence for endocrine disruption in parvathyputhen Ar., Trivandrum.Proc.Nat.Symp.Scientific Sec.Endrocrine disruptors.
- Binitha,R.N.,Oommen,O.V.,Francis Sunny.,year 2007; Sewage effluents of Parvathyputhenar influence intermediary metabolism,osmoregulation and reproduction in a fresh water fish,Anabas testudineus Proc. XXV Nat.symp.reproductive Biology and comparative Endrocrinology Abstract no.PP-29,P.128
- Binitha,R.N., Francis Sunny., year 2007; Presence of estrogenic compounds in Parvathy puthen Ar; Trivandrum: a major concern for reproduction in fish.Proc.Kerala Environmental Congress.Abstract No.PP-48,P.335
- Binitha,R.N., Francis Sunny., 2007; Presence of estrogenic compounds in Parvathy puthen Ar; Trivandrum: a major concern for reproduction in fish. Proc.Kerala Environmental Congress. Abstract No.PP-48,P.335 . (Young scientist award)
- Binitha,R.N.,Oommen,O.V.,Francis Sunny.,2007; Sewage effluents of Parvathyputhenar influence intermediary metabolism,osmoregulation and reproduction in a fresh water fish, Anabas testudineus Proc. XXV Nat.symp.reproductive Biology and comparative Endrocrinology Abstract no.PP-29,P.128
- R.N.,Binitha.,Francis Sunny.,2010;Evidence of endocrine disruption in the sewage effluents of Parvathyputhenar:Ovo-testis developed in male fish and capable of self fertilization!.Proc.XX Swadesi science congress.Abstract No:Es-06-PP.33-34
- Binitha.R.N.,Francis Sunny.,2010;Estrogenic compounds in the sewage effluents of Parvathyputhenar impair reproduction and influence intermediary metabolism in a freshwater teleost,Anabas testudineus Proc.I women science congress.PP-144
- Binitha,R.N.,Oommen,O.V.,Francis Sunny., 2011; Effect of sewage effluents on the activity of enzymes of Osmoregulation in a fresh water teleost, Anabas testudinens. Journal of reproduction and endocrinology. PP 764-66
- Binitha,R.N.,Oommen,O.V.,Francis Sunny., 2011; Effect of sewage effluents on the enzymes of intermediary metabolism in a fresh water fish,Anabastestudinens. Ecotoxicol. Environ.Safety.(Paper Communicated.)
- Soorya, S.R, Aruna Devi, C., Binitha, R.N., Amrutha, B.V., Jayalekshmy, G. and Francis Sunny., 2012; Oxidative stress experienced by freshwater fish Anabas testudinens exposed to sewage effluents of parvathyputhenar Kerala. Journal of of Biodiversity Utilization and Threats. PP-769-780.
- Young Scientist award in 3rd Environmental Congress - 2007
- Amicos Award for rank Winners – 2000 –2001
- Award for proficiency in Studies – 1999 – 2000
- Award for proficiency in Studies – 1998 – 1999
- Member in the PG board of studies Mahathma Gandhi University(4 years)
- College Level Co-ordiantor WWS programme , Office of New initiatives Govt of Kerala 2014-2020
- Research Guide Mahathma Gandhi University Faculty of Science.2018 Onwards
- CPCSEA Nominee (Ministry of Environment Forestry and climatic change). Govt of India. From 2019 January till date.
- Scientist from outside the institute in the IAEC of CIFT, Cochin.
- IQAC Criteria V Co-ordinator
- NIRF joint Co-ordinator
- WWS co-ordinator(6 years)
- Co-ordinator of Science forum( 2 Years)
- Member of Event management Committee
- IQAC sub committee member
- Research Ethics committee member